Differential Diagnosis for Proximal lower extremity weakness

45 possible diagnoses found. Too many? Narrow results

• Infected organ, Abscesses

  • Myositis, inclusion body

• Granulomatous, Inflammatory Disorders

  • Arachnoiditis lumbosacral

• Neoplastic Disorders

  • Occult malignancy/carcinoma
  • Occult tumor/cancer
  • Carcinoma, oat cell (small cell), lung
  • Lumbar spinal cord tumor
  • Metastasis to spinal cord
  • Carcinoma lung squamous cell/large cell
  • Carcinoma, adrenal cortex
  • Carcinoma, bronchogenic
  • Carcinomatous myopathy syndrome
  • Pituitary adenoma, ACTH secreting

• Allergic, Collagen, Auto-Immune Disorders

  • Dermatomyositis
  • Dermatomyositis/childhood type
  • Mixed connective tissue disease (MCTD)/Undifferentiated
  • Polymyalgia rheumatica
  • Polymyositis

• Metabolic, Storage Disorders

  • Diabetic amyotrophy syndrome
  • Porphyria, acute intermittent

• Congenital, Developmental Disorders

  • Syringomyelia

• Hereditary, Familial, Genetic Disorders

  • Muscular dystrophy
  • Muscular dystrophy, limb girdle type
  • Juvenile spinal muscle atrophy (Kugelberg-Welander)
  • Oculopharyngeal muscular dystrophy
  • Welander syndrome (See Kugelberg Welander)

• Anatomic, Foreign Body, Structural Disorders

  • Lumbar herniated disk syndrome
  • Hematomyelia
  • Lumbar Spinal stenosis

• Vegetative, Autonomic, Endocrine Disorders

  • Hyperthyroid status
  • Hyperthyroidism (Graves disease)
  • Apathetic thyroid crisis
  • Hyperparathyroidism, primary
  • Hyperparathyroidism, secondary
  • Acromegaly (Gigantism)
  • Cushing's disease/Syndrome
  • Jod-Basedow's hyperthyroidism
  • Myasthenia gravis
  • Myasthenic syndrome (Pseudomyasthenia)

• Reference to Organ System

  • Lumbar Radiculopathy

• Drugs

  • Thyroid Administration/Toxicity
  • Corticosteroid Administration/Toxicity
  • Thyroid/gland supplement
  • Cushings secondary/drug-induced syndr.
  • Steroid myopathy

• Poisoning (Specific Agent)

  • Botulism